However, this doesn’t mean HRT directly boosts the effectiveness of GLP-1 drugs—it rather creates a physiological environment where the body is better equipped to respond to them. Still, this dual-therapy approach isn’t suitable for everyone. Doctors caution that GLP-1 agonists can cause gastrointestinal side effects like nausea and abdominal pain, and may not be necessary for women with only mild weight gain or a normal BMI. Careful assessment of risks and benefits is essential before beginning such treatments.
