New research indicates that combining GLP-1 medications with hormone replacement therapy (HRT) may enhance weight-loss outcomes. For instance, a study conducted at the Mayo Clinic found that postmenopausal women using both treatments lost around 30% more weight compared to those using GLP-1 drugs alone. The presence of estrogen appears to improve the body’s overall responsiveness to these medications, possibly because it helps stabilize other menopausal symptoms like mood swings, sleep problems, and joint discomfort.
