Another issue is glutamate sensitivity. Bone broth naturally contains glutamate, a compound that can, in rare cases, trigger symptoms like headaches, anxiety, or restlessness in sensitive individuals. While scientific support for this reaction is mostly anecdotal, it’s still worth considering for those with known sensitivities. Additionally, improper preparation or storage of bone broth can lead to bacterial contamination, which might result in gastrointestinal infections. To avoid this, broth should be refrigerated or frozen promptly and thoroughly reheated before consumption.